Proteomics Core Facility Manager

Posted 05 Oct 2021

Technical University of Denmark

Denmark (Staff Scientist)

https://www.dtu.dk/english/About/JOB-and-CAREER/va...


The Proteomics Core Facility at the Department of Biotechnology and Biomedicine (DTU Proteomics Core) has an opening for a position as operational manager. The position will be available from November 1st, 2021.

The DTU Proteomics Core is a very well-equipped academic proteomics core facility and supports academic and industrial scientists both at DTU and beyond in their research by providing a wide range of proteomics services using various platforms for protein and peptide separation, state-of-the-art mass spectrometers for LC-MS analysis and specialized bioinformatics tools for data analysis. The facility provides service and engages in collaborations within advanced labeled and label-free quantitative proteomics, targeted proteomics and Data-Independent Acquisition workflows. We have a long-standing record and focus on high-sensitivity analysis of very limited sample amounts, all the way down to single cells. From November 2021, the scientific supervisors of the facility will be Associate Professor Erwin Schoof and Professor Ulrich auf dem Keller, supported by a steering committee of key proteomics researchers at DTU.

The DTU Proteomics Core is located at the DTU Lyngby campus in a recently constructed building housing ultra-modern, purpose-built laboratories for protein research. Currently, the facility hosts five ThermoFisher Orbitrap mass-spectrometers (two Eclipse Tribrids, one Exploris480 and two Q Exactive Classics), with FAIMSPro capability on the latest-generation instruments. For advanced chromatography methods, we have a U-3000 offline high pH fractionation system, and utilize online U-3000, Easy nLC1200 and EvoSep One platforms to support all modern proteomics approaches.

*Responsibilities and tasks * The position implies daily supervision of all aspects of the core facility functioning in close collaboration with the existing lab manager. The core manager is responsible for managing staff, maintaining equipment, developing and following standard operating procedures, developing and maintaining customer connections and running the projects. Budgeting and invoicing will be conducted together with the lab manager. The future of the DTU Proteomics Core will be significantly influenced by the professional contribution of the applicant. You will be involved in important biotechnological, biomedical and chemical projects, and be closely involved with on-going efforts to optimize ultra-low input workflows such as LCM tissue and single cell proteomics workflows. This includes high-profile collaborations with leading manufacturers in mass spectrometry instrument technology, chromatography and sample preparation. You will also contribute to training activities, including giving technical introductions to the customers, as well as supervision of visiting students and postdocs. Own research in technological developments in proteomics will be strongly encouraged. Applying for own research grants is not obligatory but highly recommended.

Qualifications Candidates should have a PhD or equivalent, with documented experience in day-to-day handling of modern mass spectrometry instrumentation of at least 2-3 years. For this position, a service-oriented personality as well as a high social competence are essential. The ideal candidate has a strong background in mass spectrometry and proteomics, as well as excellent understanding of the technology involved, including liquid chromatography, high-resolution mass spectrometry, bioinformatics and related software. A strong grasp on approaches such as DDA, DIA, PRM, SureQuant and Tomahto is essential, including downstream analysis using e.g. Proteome Discoverer, Spectronaut, Spectromine, MaxQuant or Skyline.

The applicant should possess at least a core understanding of biochemistry, molecular biology, and biotechnology and be familiar with typical proteomics tasks. Organizational, managerial, leadership and interpersonal skills are of particular importance. The ideal applicant must have strong motivation and excellent work ethics. The ability to effectively interact with the research and technical staff within the group as well as external researchers in a team-oriented manner is a must. Advanced knowledge of English is essential as this is the working language.

Perks

We offer an interesting and challenging job in an international environment focusing on education, research, scientific advice and innovation, which contribute to enhancing the economy and improving social welfare. You will be at the cutting edge of proteomics research, with a wide range of workflows to be supported and further developed. We strive for academic excellence, collegial respect and freedom tempered by responsibility. The Technical University of Denmark (DTU) is a leading technical university in northern Europe and benchmarks with the best universities in the world. The appointment will be based on the collective agreement with the Confederation of Professional Associations. The allowance will be agreed with the relevant union. The position is initially available for 3 years.

How to Apply

Please submit your online application no later than October 31st. However, applications received will be reviewed on a rolling basis to ensure a timely process. Applications must be submitted as one PDF file containing all materials to be given consideration. To apply, please open the link "Apply online," fill in the online application form, and attach all your materials in English in one PDF file. The file must include: • Application (cover letter) • CV • Diploma (MSc/PhD) • List of publications Applications and enclosures received after the deadline will not be considered. All interested candidates irrespective of age, gender, disability, race, religion or ethnic background are encouraged to apply.