Postdoc Position: Proteomic investigations of the DNA damage response

Posted 07 Jan 2019

Institute of Molecular Biology gGmbH (IMB)

Germany (Post Doc)

https://www.imb.de/


The Institute of Molecular Biology (IMB, www.imb.de) is a centre for basic research on the campus of Mainz University, Germany. We are generously funded by the Boehringer Ingelheim Foundation and the state of Rhineland-Palatinate. Our research focuses on the biology of the cell nucleus, ranging from the molecular to the organismic level. IMB researchers are supported by strong core facilities (www.imb.de/core-facilities) that offer state-of-the-art services in bioinformatics, cytometry, genomics, histology and microscopy, proteomics, and protein production. IMB’s working language is English.

In this competitive call, we are recruiting talented and ambitious scientists worldwide. At IMB, you will work on cutting-edge research projects in a highly international and interdisciplinary environment. IMB’s Postdoc Programme (IPPro) is specifically designed to meet the needs of postdocs and to equip them for a successful career in research. We offer advanced training in scientific techniques and professional skills, provide mentorship and networking opportunities, actively support your career development, and assist you with raising funds for yourself and for your projects. This will ensure that you can work efficiently and are prepared for the next step in your career.

In our 2018/19 call, we offer a postdoc position in the lab of Dr Petra Beli focussing on "Proteomic investigations of the DNA damage response":

Scientific background:

We are seeking for a highly motivated molecular biologist to join the research group of Petra Beli at the Institute of Molecular Biology (IMB) in Mainz as a postdoctoral fellow. The Beli laboratory uses mass spectrometry-based proteomics to obtain a systems-view of the DNA damage response and Ubiquitin signaling.

The project:

The recruitment of DNA repair factors to sites of DNA damage is a dynamic process that is tightly regulated by posttranslational modifications of proteins, in particular phosphorylation and ubiquitylation. The full scope of proteins functioning at different types of DNA lesions, and the mechanisms that lead to the regulated recruitment of factors to these sites are not understood. In this project we will employ in vivo proximity tagging based on engineered ascorbate peroxidase (APEX) combined with quantitative mass spectrometry to investigate the recruitment of proteins and the formation of protein complexes at sites of DNA damage. The function of newly identified factors will be investigated on a molecular level using high throughput microscopy and functional DNA repair assays.

Starting date: 1 May 2019 or later

How to Apply

Prior to applying, please see www.imb.de/postdocs for details on the projects offered. To apply, please send a single PDF, containing your cover letter, CV, and a concise description of your research interests and future research plans to postdoc@imb.de. Please also arrange for two letters of recommendation to be sent to postdoc@imb.de. IMB is an equal opportunity employer.

The deadline for applications is 29 January 2019. Interviews will take place in Mainz on 2-3 April 2019.

Declaration of consent and data protection:

By sending us your application, you consent to us saving your personal data in order to carry out the selection process. You can find more information on data protection and retention periods at www.imb.de/jobs/datenschutzerklaerung-data-protection.