Postdoc Position: Protein Quality Control

Posted 07 Jan 2019

Institute of Molecular Biology gGmbH (IMB)

Germany (Post Doc)

The Institute of Molecular Biology (IMB, is a centre for basic research on the campus of Mainz University, Germany. We are generously funded by the Boehringer Ingelheim Foundation and the state of Rhineland-Palatinate. Our research focuses on the biology of the cell nucleus, ranging from the molecular to the organismic level. IMB researchers are supported by strong core facilities ( that offer state-of-the-art services in bioinformatics, cytometry, genomics, histology and microscopy, proteomics, and protein production. IMB’s working language is English.

In this competitive call, we are recruiting talented and ambitious scientists worldwide. At IMB, you will work on cutting-edge research projects in a highly international and interdisciplinary environment. IMB’s Postdoc Programme (IPPro) is specifically designed to meet the needs of postdocs and to equip them for a successful career in research. We offer advanced training in scientific techniques and professional skills, provide mentorship and networking opportunities, actively support your career development, and assist you with raising funds for yourself and for your projects. This will ensure that you can work efficiently and are prepared for the next step in your career.

In our 2018/19 call, we offer one postdoc position in the lab of *Dr Anton Khmelinskii focussing on "Protein Quality Control*":

Scientific background:

We are focused on mechanisms of proteome turnover, surveillance and quality control. Working in yeast and human cells, we aim at understanding the selectivity in the ubiquitin-proteasome system and its roles in quality control of mislocalized proteins. We employ high-throughput genetic and proteomic assays in combination with cell/molecular biology and biochemical approaches, and develop new methods, to elucidate how cells identify abnormal proteins and to explore links between protein quality control, cancer and ageing.

The project:

We are seeking to recruit an outstanding candidate with a strong background in cell and molecular biology and experience with budding yeast as a model system. Candidates with expertise in high-throughput yeast genetics or proteomic approaches and good knowledge of analytical tools such as R are especially encouraged to apply. The successful candidate will join a highly motivated international team and develop a cutting-edge project, funded by an ERC Starting Grant, to dissect mechanisms of quality control for mislocalized proteins. With strong support for genomics and proteomics from IMB Core Facilities, the project is aimed at identifying systems involved in quality control of different types of mislocalized proteins, understanding the mechanisms of substrate recognition and uncovering the functions of such quality control systems under normal and stress conditions.

Applications should include a statement of interests and a brief project proposal (max. 1 page). Informal enquires should be addressed to Dr. Anton Khmelinskii (a.khmelinskii(at)

Starting date: 1 May 2019 or later

How to Apply

Prior to applying, please see for details on the projects offered. To apply, please send a single PDF, containing your cover letter, CV, and a concise description of your research interests and future research plans to Please also arrange for two letters of recommendation to be sent to IMB is an equal opportunity employer.

The deadline for applications is 29 January 2019. Interviews will take place in Mainz on 2-3 April 2019.

Declaration of consent and data protection:

By sending us your application, you consent to us saving your personal data in order to carry out the selection process. You can find more information on data protection and retention periods at