The German Center for Neurodegenerative Diseases (DZNE) is a world-leading internationally oriented research center, committed to discovering new approaches to prevent and treat neurodegenerative diseases. To this end, researchers at ten DZNE sites across Germany pursue a translational and interdisciplinary strategy comprising five interconnected areas: fundamental research, clinical research, health care research, population health science, and systems medicine (www.dzne.de).
For the DZNE site in Ulm, we are inviting applications for a *PhD student (f/m/d) in the group “Translational Mass Spectrometry and Biomarker Research (Oeckl lab)” Code – 6033/2023/10 *
The Oeckl lab (www.oeckllab.com) uses state-of-the-art mass spectrometry for the discovery, characterization and implementation of fluid biomarkers (blood, cerebrospinal fluid) for neurodegenerative diseases such as Alzheimer´s disease, amyotrophic lateral sclerosis (ALS) or frontotemporal dementia. We use proteomic/peptidomic approaches in patient samples to discover novel biomarker candidates which might improve (early/differential) diagnosis, disease monitoring or drug development (e.g. Oeckl et al., Acta Neuropathol 2020). To characterize specific biomarker candidates and the related pathomechanisms in detail (e.g. synaptic marker beta-synuclein in blood), we develop highly sensitive and accurate methods using targeted mass spectrometry (MRM, PRM, IP-MS) to study samples from large patient cohorts and evaluate their value for use in the clinic or drug development (e.g. Oeckl et al., Alzheimers Dement 2023). These assays are also intended to be used as reference measurement procedures in round robins and biomarker implementation. For promising biomarker candidates, we also develop highly sensitive immunoassays (ELISA, Simoa, Ella) for routine clinical application. The association of the Oeckl lab to the Neurology Department of the Ulm University Hospital provides excellent interaction with neurologists and psychologists and access to well-characterized patient samples enabling highly clinically-oriented research. We have our own equipment for highly competitive biomarker research including state-of-the-art mass spectrometry (Exploris 480 with FAIMS, QTRAP6500), immunoassay instruments (Simoa, Ella) and devices for sample handling (e.g. KingFisher Apex, Viaflo96).
The DZNE is an equal opportunity employer. It is committed to employing disabled individuals and especially encourages them to apply.
consistent with those at other research institutes
Please apply via the official website: