The EDyP research team develops integrated multidisciplinary approaches, in particular analytical and computational methods, to answer biological questions and meet health needs through high-throughput characterisation of proteins and proteomes. EDyP draws on the complementary expertise of over thirty staff-members, who develop research projects based on innovative proteomics approaches, and provide services to the academic and industrial communities. The technological platform at EDyP is equipped with state-of-the -art instrumentation. The laboratory is renowned nationally and internationally for its proteomics analysis know-how. For a number of years, EDyP laboratory has been undertaking research projects in biology and analytical and computational science. In particular, in collaboration with clinicians, EDyP works to identify and assess new protein biomarkers, in particular linked to chronic diseases, by analysing the proteomes of clinical samples from patient cohorts (deep molecular phenotyping).

EDyP wishes to strengthen its research activity in the health field. In this context, the team is seeking to recruit a researcher (permanent position - CEA) with advanced expertise in the biomedical field who will contribute to the challenges that proteomics can meet in this field. The candidate will strengthen the themes developed in the laboratory by developing its own research projects in the field of human health, taking advantage of the analytical and computational capacities developed within the team. In addition, the candidate must have a demonstrated capacity to establish national and international collaborative networks. A history of interaction with clinical entities will be considered a plus.

The candidate will be responsible for:

• Coordinating research projects relating to the discovery and assay of proteins of interest to medicine (biomarkers, therapeutic targets, etc.) using innovative proteomics analysis methods.
• Contributing to methodological innovation in the laboratory.
• Establishing scientific collaborations, in particular with clinicians, and seeking out funding.
• Contributing to the team’s scientific development, in particular through scientific and technological monitoring.
• Supervising permanent and non-permanent staff members (post-doctoral fellows, PhD candidates, and Master’s students).
• Disseminating and exploiting results.

The candidate will also contribute to the team, the research unit, and the institution through scientific animation, and by applying the quality assurance system to the projects managed.

Applicant profile Candidates should have a PhD in biology, biochemistry, biotechnology, or medicine, and at least three years’ experience in the biomedical field, in particular undertaking projects involving “omics” approaches. The candidates will need to demonstrate their capacity to:

• Exploit studies undertaken, in particular by writing scientific articles for publication in international peer-reviewed journals (publications as first and/or last author).
• Draft projects in response to calls for proposals to obtain funding for their scientific activity.
• They should also be comfortable with scientific English. Key characteristics of the ideal candidate include a strong team spirit, good organisational skills, self-sufficiency, meticulousness and dynamic attitude. Their core values will include strict application of ethical scientific practices.

Organisation The French Alternative Energies and Atomic Energy Commission (CEA) is a key player in research, development and innovation in four main areas:

• defence and security
• nuclear energy (fission and fusion)
• technological research for industry
• basic research in the physical and life sciences

Drawing on its widely acknowledged expertise, and thanks to its 16000 technicians, engineers, researchers and research-support staff, the CEA actively participates in collaborative projects with a large number of academic and industrial partners. The CEA is established in ten centres spread throughout France

Division description The interdisciplinary research institute of Grenoble (Irig; https://www.cea.fr/drf/irig) was created in 2019 and consists of 10 mixed research units (UMR). The UMR are engaged in basic research in biology, health, nanosciences, cryotechnology, and new energy-related and environmental technologies. Physicists, chemists, biologists, medical doctors, computer scientists and mathematicians work together on this research and the resulting applications, providing Irig with a remarkable capacity to respond to major societal challenges in the fields of health, energy and information technology.

Description of the research unit EDyP laboratory (Exploring the Dynamics of Proteomes) is a department of an INSERM/CEA/UGA UMR. Its objective is to explore living systems using multi-scale approaches to garner new basic knowledge and seek innovative therapeutic solutions for applications in personalised medicine. Geographically, EDyP is located near several large European infrastructures (EMBL, ESRF, ILL) and other Grenoble-based health-research structures. The area thus attracts a very high-level international scientific community thanks to a dynamic labour market and a high proportion of students. The presence of Université Grenoble Alpes, accredited as an Initiative of Excellence (Idex) by the French government in 2016, is an added advantage.

For further information on the position, please contact Christophe Bruley (christophe.bruley@cea.fr) and Yohann Couté (yohann.coute@cea.fr).

Deadline for submission of applications: 20/08/2022